白藜芦醇对大鼠慢性阻塞性肺疾病的干预作用及其机制

被引：11

作者：

周敏

何建林

余书勤

朱瑞芳

陆晶

丁福云

绪广林

机构：

[1] 南京师范大学生命科学学院新药中心

来源：

药学学报 | 2008年 / 02期

关键词：

白藜芦醇; 慢性阻塞性肺疾病; 支气管肺泡灌洗液; 细胞间粘附分子-1;

D O I：

10.16438/j.0513-4870.2008.02.002

中图分类号：

R285 [中药药理学];

学科分类号：

摘要：

研究白藜芦醇对大鼠慢性阻塞性肺疾病的作用及可能的机制。单次气管注射博莱霉素(BLM)及连续27d烟熏建立大鼠COPD模型,检测动脉血气参数变化、肺功能指标,测定支气管肺泡灌洗液(BALF)中细胞间粘附分子-1(ICAM-1)含量,检测肺湿/干重(W/D)比值,观察组织病理学变化。实验发现,白藜芦醇能抑制大鼠COPD的PaO2的下降,升高FEV0.3/FVC的比值,降低BALF中ICAM-1的含量,降低肺W/D比值,减轻肺组织病理学损伤。结果提示,白藜芦醇对大鼠COPD具有干预作用,其作用机制可能与抑制炎症因子的释放有关。

引用

页码：128 / 132

页数：5

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