硝普钠对组胺所致离体豚鼠回肠H1效应的影响

被引：4

作者：

赵蕊

楼宜嘉

赵轶

机构：

[1] 浙江大学药学院药理学与毒理学研究室,浙江大学药学院药理学与毒理学研究室,浙江大学药学院药理学与毒理学研究室浙江杭州,浙江杭州,浙江杭州

来源：

中国药理学与毒理学杂志 | 2002年 / 02期

关键词：

一氧化氮; 硝普钠; 组胺; 硝苯地平; 回肠; 钙; 胃肠活动;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的　探讨一氧化氮 (NO)与组胺 (His)对离体豚鼠回肠生理活动的共同调节作用及其可能机理。方法　将离体回肠段固定于含 95 %O2 和 5 %CO2 台氏液恒温测试系统中 (37℃ ) ,分别给予硝普钠 (SNP ,15、15 0、15 0 0 μmol·L- 1)或SNP +硝苯地平(Nif ,2 5、5 0、10 0nmol·L- 1) ,作用 30min ,再累积加入不同浓度的His(0 .0 1～ 10 μmol·L- 1) ,以平衡生理记录仪描记肠段收缩曲线 ,观察SNP和Nif对His引起的回肠H1效应的影响。结果　①SNP可增强低浓度His(0 .0 1～ 0 .1μmol·L- 1)引起的回肠H1效应 ,随His浓度增高 ,SNP的增强作用减弱 ;②去台氏液中外钙 ,有或无SNP存在时的HisH1效应均呈减弱作用 ,且两者间无显著差别 ;③Nif呈浓度依赖性地抑制His引起的H1效应 ,并浓度依赖性地抑制SNP增强H1效应的作用。结论　SNP可增强离体豚鼠回肠HisH1效应 ,该增强作用可能与回肠平滑肌细胞的外Ca2 + 内流有关。

引用

页码：93 / 97

页数：5

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