长链非编码RNAs与细胞分化

被引：3

作者：

吴文桢 ^{[1
,2
]}

王开娟 ^{[3
]}

王家伟 ^{[1
]}

机构：

[1] 武汉大学口腔医学院

[2] 兰州市口腔医院

[3] 兰州大学口腔医学院

来源：

口腔医学研究 | 2017年 / 33卷 / 10期

关键词：

长链非编码RNAs; 细胞分化; 机制;

D O I：

10.13701/j.cnki.kqyxyj.2017.10.027

中图分类号：

R781 [口腔内科学];

学科分类号：

100201 [内科学];

摘要：

随着遗传学及生物信息学技术的快速发展,曾被称为转录"噪音"的长链非编码RNAs(Long non-coding RNAs,LncRNAs)越来越受到学者们的广泛关注。研究发现,LncRNAs在生物体各种生命活动中具有重要的调节作用,其对基因表达的调控作用已成为生命科学研究的热点问题。研究证实,LncRNAs通过信号分子、诱饵分子、引导分子、支架分子等方式,对遗传、转录及转录后等进行水平调控,如细胞分化等生物学过程。本文就LncRNAs与细胞分化的关系作一综述,包括LncRNAs与多能干细胞多能性的维持及分化、与神经细胞分化、与肌肉分化、与成骨细胞分化的机制,以及LncRNAs与口腔鳞状细胞癌的关系。

引用

页码：1127 / 1130

页数：4

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