帕罗西汀合并奥氮平治疗伴躯体症状抑郁症的对照研究

被引：20

作者：

刘彩兴

董继承

薛晓斌

冯玉芳

机构：

[1] 山东省青岛市精神卫生中心

来源：

精神医学杂志 | 2008年 / 03期

关键词：

帕罗西汀; 奥氮平; 抑郁症;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

摘要：

目的探讨帕罗西汀合并奥氮平治疗伴躯体症状抑郁症的疗效及安全性。方法66例伴躯体症状的抑郁症患者随机分为帕罗西汀组33例,帕罗西汀合用奥氮平组33例,共治疗8周。于治疗前,治疗后1、2、4、8周末采用汉密尔顿抑郁量表(HAMD),副反应量表(TESS)评定疗效和副反应。结果帕罗西汀合用小剂量奥氮平组疗效显著,合用药组与单用药组的显效率分别是84.85%和60.61%,差异有显著性(χ2=4.89,P<0.05)。两组的HAMD因子分在焦虑/躯体化和睡眠障碍方面差异有显著性;两组副作用均较小。结论帕罗西汀合用小剂量奥氮平治疗抑郁症起效快,可提高疗效,能迅速改善睡眠障碍和躯体症状。

引用

页码：207 / 209

页数：3

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