脂蛋白脂酶基因Ser447Ter变异对血脂的影响

被引：9

作者：

赵水平

仝其广

聂赛

周宏年

肖志杰

机构：

[1] 中南大学湘雅二院心内科,中南大学湘雅二院心内科,中南大学湘雅二院心内科,中南大学湘雅二院心内科,中南大学湘雅二院神经内科长沙,长沙,长沙,长沙,长沙

来源：

中华心血管病杂志 | 2003年 / 02期

关键词：

脂蛋白脂酶; 突变; 危险因素; 冠状动脉疾病;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

目的　探讨脂蛋白脂酶 (LPL)基因Ser447Ter变异是否影响血脂水平。方法　 2 52例受试者 ,其中 1 32例冠心病患者及 1 2 0例非冠心病者。采用聚合酶链式反应限制性片段多态性方法检测LPL基因多态性。结果　LPL基因Ser447Ter突变杂合子 (CG型携带者 )和纯合子 (GG型携带者 )血甘油三酯浓度 [(1 1 7± 0 55)mmol L]低于无Ser447Ter突变者 [CC型携带者 ,(1 64± 1 1 1 )mmol L] ,P<0 0 1 ;前者高密度脂蛋白胆固醇水平 [(1 2 4± 0 2 7)mmol L]高于后者 [(1 1 3± 0 2 7)mmol L] ,P <0 0 5 ;这种效应女性携带者更为明显。但是 ,男女两性Ser447Ter各基因型的比例相近。结论　LPLSer447Ter突变可影响血脂水平 ,且存在男女性别差异 ,各LPL基因型的分布无性别差异

引用

页码：24 / 27

页数：4

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