多巴胺受体D2基因C957T多态性与抑郁症患者改良电休克治疗疗效的相关性研究

被引:5
作者
张春平
黄雄
何红波
刘榴
王志杰
江妙玲
古智文
张敏玲
机构
[1] 广州市精神病医院
关键词
抑郁症; 多巴胺受体2; 改良性电抽搐治疗;
D O I
暂无
中图分类号
R749.4 [情感性精神病];
学科分类号
摘要
目的:探讨抑郁症患者多巴胺受体D2基因C957T多态性与改良性电休克治疗(MECT)疗效的关系。方法:采用病例对照研究方法,选取病例组100例和对照组100例,运用聚合酶链式反应-直接测序法,检测多巴胺受体D2基因C957T多态性;对病例组进行8次MECT治疗,并于治疗前后进行汉密顿抑郁量表评定,根据测序结果及量表评定结果综合分析基因型与MECT的疗效关系。结果:MECT疗效与DRD2-C957T基因多态性无关联,疗程结束两组基因分型疗效差异无统计学意义(P>0.05)。但CT基因型患者于治疗第2、4、6次的HAMD分值显著低于CC基因型,治疗第2次和第4次减分率显著高于CC基因型。结论:CT基因型对MECT的反应性较好,起效迅速。
引用
收藏
页码:2826 / 2828
页数:3
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