口蹄疫自然感染动物与免疫动物鉴别诊断研究进展

被引：9

作者：

曹轶梅

卢曾军

刘在新

谢庆阁

机构：

[1] 中国农业科学院兰州兽医研究所农业部病毒学重点实验室

[2] 中国农业科学院兰州兽医研究所农业部病毒学重点实验室甘肃兰州

[3] 甘肃兰州

来源：

动物医学进展 | 2003年 / 06期

关键词：

口蹄疫; 自然感染动物; 免疫动物; 鉴别诊断;

D O I：

10.16437/j.cnki.1007-5038.2003.06.007

中图分类号：

S855.3 [病毒病];

学科分类号：

0906 ;

摘要：

口蹄疫是偶蹄动物高度接触性传染病 ,能引起巨大经济损失。国际兽医局将其列为 A类动物传染病之首。除发达国家外 ,大多数发展中国家都采用注射疫苗的办法来控制该病的流行。因此如何区分感染动物和免疫动物是口蹄疫防制中迫切需要解决的问题。目前口蹄疫灭活疫苗的生产工艺可以将绝大部分的非结构蛋白除去 ,因而灭活疫苗免疫动物只能产生结构蛋白抗体 ,而感染动物能产生结构蛋白抗体 ,也能产生非结构蛋白抗体 ,因此 ,检测非结构蛋白抗体为鉴别口蹄疫感染动物与免疫动物提供了美好前景。文章从鉴别诊断的原理 ,非结构蛋白的免疫特性 ,鉴别诊断所面临的问题及解决方案 ,应用非结构蛋白作为鉴别诊断抗原的研究现状等方面进行了综述。

引用

页码：22 / 24

页数：3

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