脂多糖诱导鼠脑中的白细胞介素-6基因表达

被引:2
作者
徐运
袁成林
俞龙
机构
[1] 扬州大学医学院附院神经科
关键词
脂多糖; 脑中白细胞介素-6; 基因表达;
D O I
暂无
中图分类号
Q785 [转化及克隆];
学科分类号
071007 ; 0836 ; 090102 ;
摘要
目的 分子水平研究正常鼠脑内的白细胞介素-6(IL-6)分布和诱导水平。方法 脂多糖(LPS)100 ug/kg,ip,不同时间,用PT-RCR对鼠脑的6个不同区域,进行IL-6信使核糖核酸(m RNA)半定量分析。结果 IL-6 m RNA表达由高到低依次为海马、下丘脑、脑干、小脑、丘脑和皮层。除皮层表达高峰在6小时外,其余在4 小时。结论 LPS诱导的IL-6 m RNA 在正常鼠脑的不同部位表达曲线不同。
引用
收藏
页码:259 / 260
页数:2
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