AOM/DSS模型与炎症相关癌变研究进展

被引：33

作者：

林凯璇 ^{[1
]}

瞿秀华 ^{[2
]}

赵晓航 ^{[2
,3
]}

机构：

[1] 南方医科大学

[2] 中国人民解放军海军总医院

[3] 中国医学科学院肿瘤研究所分子肿瘤学国家重点实验室

来源：

生命科学 | 2012年 / 24卷 / 03期

关键词：

动物模型; 氧化偶氮甲烷/葡聚糖硫酸钠; 炎症相关癌症形成;

D O I：

10.13376/j.cbls/2012.03.003

中图分类号：

R-332 [医用实验动物学];

学科分类号：

100402 [劳动卫生与环境卫生学];

摘要：

氧化偶氮甲烷(azoxymethane,AOM)/葡聚糖硫酸钠(dextran sodium sulfate,DSS)小鼠模型是一种在致癌剂AOM和致炎剂DSS协同作用基础上,由炎症性肠病(inflammatory bowel disease,IBD)逐步发展为结直肠癌的炎症相关性癌症的研究模型。AOM/DSS模型能很好地模拟慢性肠道炎症诱发癌症的生理病理过程,近年来被广泛用于炎症相关性癌症形成机制的研究。简要综述AOM/DSS模型与炎症相关性癌症癌变机理的研究进展。

引用

收藏

页码：228 / 235

页数：8

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