用组织芯片技术研究JAK/Stat 5在肝癌组织中的表达及意义

被引：2

作者：

赵军艳

殷飞

姚树坤

机构：

[1] 河北医科大学第四临床医院消化内科

来源：

中国组织化学与细胞化学杂志 | 2006年 / 01期

关键词：

组织芯片; 肝癌; JAK; Stat5; 信号转导;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

目的研究肝癌中心癌组织、边缘癌组织和非癌肝硬化组织中JAK/Stat 5的表达特性及其意义。方法利用组织芯片技术和免疫组化SP法检测JAK/Stat 5在肝癌组织和非癌肝硬化组织的表达。结果中心癌组织JAK、Stat 5平均光密度值明显高于边缘癌组织(P<0.05);中心癌组织、边缘癌组织JAK、Stat 5表达率及表达强度明显高于非癌肝硬化组织;JAK、Stat 5表达阳性率与肝癌病理类型、分化程度无关。结论JAK、Stat 5表达与肝癌发生有密切关系,JAK/Stat 5表达异常可能在细胞恶性转化中起重要作用;边缘癌组织中JAK、Stat 5呈阳性表达的肝细胞可能是具有恶性潜能的癌前细胞群。

引用

页码：95 / 100

页数：6

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