IGF-1对中枢神经系统保护作用的研究进展

被引:8
作者
乔彦霞
机构
[1] 石家庄市第四医院儿科河北石家庄
关键词
胰岛素样生长因子1; 中枢神经系统; 脑缺氧; 脑缺血;
D O I
暂无
中图分类号
R741.05 [神经病治疗学];
学科分类号
1002 ;
摘要
胰岛素样生长因子-1(IGF-1)广泛分布于中枢神经系统和外周神经系统,并通过内分泌、自分泌和旁分泌发挥作用,以高浓度存在于脑脊液中,IGF-1变化同脑脊液变化一致。通过调节细胞内Ca3+、酶活性、脑糖代谢来调节脑的生长和分化,维持成年脑正常功能,减轻缺氧缺血对中枢神经系统造成的损伤,防止神经细胞凋亡,有助于神经细胞受损后功能恢复,对神经组织生长、发育也起着非常重要的作用。
引用
收藏
页码:129 / 131
页数:3
相关论文
共 15 条
[1]  
Insulin and insulin-like growth factor-1 inhibit the L-type calcium channel current in rat pinealocytes. Chik CL,Li B,Karpinski E,et al. The Journal of Endocrinology . 1997
[2]  
The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injur in adult rats: evidence for a role for IGF binding proteins. Guan J,Williams CE,Skinner SJ,et al. European Journal of Endocrinology . 1996
[3]  
Insulin-like growth factors cross the blood-brain barrier. Reinhardt RR,Bondy CA. The Journal of Endocrinology . 1994
[4]  
The insulin-like growth factors. Cohick WS,Clemmons DR. Annual Review of Physiology . 1993
[5]  
Growth,differentiation, and survival: multiple physiological functions for insulin-like growth factors. Stewart CE,Rotwein P. Physiological Reviews . 1996
[6]  
Ca (2+)-andCl(-)-dependent, NMDA receptor-mediated neuronal death induced by depolarization in rat hippocampal organotypi cultures. Takahashi M,Liou SY,Kunihara M. Brain Research . 1995
[7]  
Insulin-like growth factor-1 induces a rapid increase in calcium currents and spontaneous membrane activity in clonal pituitary cells. Selinfreund RH,Blair LA. Molecular Pharmacology . 1994
[8]  
Insulin-like growth factor 1 regulates developing brain glucose metabolism. Cheng CM,Reinhardt RR,Lee WH,et al. Proceedings of the National Academy of Sciences of the United States of America . 2000
[9]  
Insulin-like growth factor-1 is a potent neuronal rescue agen after hypoxic-ischemic injury in fetal lambs. Johnston BM,Mallard EC,Williams CE,et al. The Journal of Clinical Investigation . 1996
[10]  
The insulin-like growth factor I system in the rat cerebellum: developmental regulation and role in neuronal survival and differentiation. Torres-Aleman I,Pons S,Arevalo MA. Journal of Neuroscience Research . 1994