抗流感病毒抗生素研究开发进展(英文)

被引：1

作者：

顾觉奋

韩方

机构：

[1] 中国药科大学

来源：

中国抗生素杂志 | 2004年 / 07期

关键词：

流感病毒; 新型抗流感病毒抗生素; 计算机分子模拟设计;

D O I：

10.13461/j.cnki.cja.003554

中图分类号：

R978 [治疗传染病及寄生虫病药物];

学科分类号：

摘要：

流感是严重危害人类健康的急性病毒性呼吸道传染病 ,由于流感病毒抗原变异 ,常规疫苗尚不能有效预防流感的暴发与流行。因此 ,抗流感病毒药物研究在流感治疗中具有重要意义。本文就近年来国外抗流感病毒药物研究进展 ,包括微生物来源的新型抗生素司他弗林 (stachyflin)和乙酰司他弗林 (acetylstachyflin) ,FR1982 4 8,FR1915 12 ,10 - norparvulenone的发现 ,以及经计算机分子模拟设计的氨基酸类 NA抑制剂、环戊烷类 NA抑制剂 RWJ- 2 70 2 0 1(BCX- 1812 )等的开发情况进行概述。

引用

页码：443 / 449

页数：7

共 13 条

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