肿瘤多药耐药逆转剂研究进展

被引:14
作者
于韬
赵桂森
臧恒昌
牛华英
景永奎
机构
[1] 山东大学药学院
[2] Mount Sinai School of Medicine 山东济南
[3] 山东济南
[4] New York
[5] -
关键词
药物化学; 构效关系; 综述; 多药耐药逆转剂; P-糖蛋白抑制剂; 谷胱甘肽S转移酶抑制剂;
D O I
10.14142/j.cnki.cn21-1313/r.2003.03.015
中图分类号
R979.1 [抗肿瘤、抗癌药物];
学科分类号
1007 ;
摘要
化疗是治疗肿瘤的主要手段之一 ,多药耐药性的产生是肿瘤化疗中存在的主要问题。开发多药耐药逆转剂 ,逆转现有化疗药物的耐药性将是一种有效的治疗方法。目前已有多种多药耐药逆转剂处于基础和临床试验阶段。本文对近年来多药耐药逆转剂的研究概况做了简要阐述。
引用
收藏
页码:55 / 61
页数:7
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