轻度认知障碍患者脑脊液中β-淀粉样蛋白42及磷酸化Tau蛋白的水平检测及意义

被引:16
作者
韩丽珠 [1 ]
王文静 [1 ]
褚忠海 [1 ]
吴元波 [1 ]
吴蕾 [1 ]
程昭昭 [1 ]
孙安源 [2 ]
机构
[1] 安徽医科大学附属省立医院神经内科
[2] 安徽医科大学附属省立医院检验科
关键词
认知障碍; β-淀粉样蛋白42; 磷酸化Tau蛋白; 脑脊液;
D O I
暂无
中图分类号
R749.1 [脑器质性精神障碍];
学科分类号
摘要
目的:探讨轻度认知障碍(MCI)患者脑脊液中β-淀粉样蛋白42(Aβ42)与磷酸化Tau蛋白(P-tau)水平变化及其意义。方法:采用ELISA法检测25例MCI患者和14例认知功能正常者脑脊液标本中Aβ42和P-tau水平,并对MCI患者脑脊液中P-tau和MMSE评分进行相关统计学分析。结果:MCI组脑脊液中Aβ42水平低于对照组,P-tau水平高于对照组,差异有统计学意义(P<0.05)。简单相关分析及校正受教育程度后的偏相关分析显示MCI组脑脊液中P-tau水平与MMSE评分呈负相关(P<0.05)。结论:脑脊液中Aβ42和P-tau水平可能为MCI诊断提供依据。MCI患者中脑脊液P-tau水平可能与认知障碍的严重程度有关。
引用
收藏
页码:3079 / 3081
页数:3
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