顶空毛细管气相色谱法测定氯雷他定中9种有机溶剂的残留量

提出了顶空毛细管气相色谱法测定氯雷他定中乙醚、异丙醇、乙腈、叔丁醇、乙酸乙酯、四氢呋喃、环己烷、三乙胺和甲苯的残留量。采用DB-624毛细管柱(30 m×0.53 mm,3μm),程序升温,以N、N-二甲基甲酰胺(DMF)为溶剂,9种溶剂的平均回收率分别为98.2%,98.8%,106.0%,99.0%,97.7%,95.4%,95.1%,93.0%,100.6%,检出限分别为0.056,0.67,0.61,0.45,0.33,0.16,0.041,0.28,0.20 mg.L-1,测定限分别为0.17,2.0,1.9,1.1,1.1,0.54,0.13,0.90,0.69 mg.L-1。