超高效液相色谱-串联质谱法同时检测环境水中5种苯二氮卓类镇静剂药物

被引：13

作者：

张力群 ^{[1
]}

金铨 ^{[1
]}

刘少颖 ^{[1
]}

黄希汇 ^{[1
]}

何华丽 ^{[1
]}

吴平谷 ^{[2
]}

机构：

[1] 杭州市疾病预防控制中心

[2] 浙江省疾病预防控制中心

来源：

中国卫生检验杂志 | 2018年 / 28卷 / 02期

关键词：

生活饮用水; 苯二氮卓; 镇静剂; 液相色谱-串联质谱;

D O I：

暂无

中图分类号：

O657.63 [质谱分析]; X832 [水质监测];

学科分类号：

070302 [分析化学]; 090810 [水产品加工与质量安全];

摘要：

目的建立同时测定环境水中的地西泮、硝西泮、去甲西泮、奥沙西泮、氟胺安定等5种苯二氮卓类镇静剂的检测方法。方法 500 ml环境水样品以5.0 ml/min流速过HLB固相萃取柱富集、洗脱收集后,以D5-地西泮为内标,直接超高效液相色谱-串联质谱（UPLC-MS/MS）进样分析。采用Waters BEH C18柱（50 mm×2.1 mm,1.7μm）,流动相为0.1%的甲酸水溶液和乙腈,梯度洗脱,流速:0.3 ml/min;质谱检测器采用ESI电离源,正离子多反应监测（MRM）扫描分析。结果地西泮、硝西泮、去甲西泮、奥沙西泮、氟胺安定等5种苯二氮卓类镇静剂药物在0.2 ng/L200 ng/L内,线性关系良好（r值为0.996 9～0.999 6）,最低检出限为0.1 ng/L0.4 ng/L,最低定量限为0.3 ng/L1.3 ng/L;在生活饮用水中添加5种镇静剂浓度分别为2.0 ng/L、20.0 ng/L、100.0 ng/L时,平均回收率为88.3%109.2%,相对标准偏差为2.2%9.8%。结论该方法快速、灵敏、准确度高,适用于生活饮用水中多种苯二氮卓类镇静剂的含量监测。

引用

页码：142 / 145

页数：4

共 14 条

[1]

脉冲不分流进样气相色谱-质谱法分析血浆中的10种镇静催眠药 [J].

常青 ;

马虹英 ;

王方杰 ;

欧红莲 ;

邹明 .

色谱, 2011, (11) :1082-1086

[2]

A rapid ultrasound-assisted dispersive liquid–liquid microextraction followed by ultra-performance liquid chromatography for the simultaneous determination of seven benzodiazepines in human plasma samples.[J].Purificación Fernández;Cristina González;M. Teresa Pena;Antonia M. Carro;Rosa A. Lorenzo.Analytica Chimica Acta.2013,

[3]

Restricted access magnetic core-mesoporous shell microspheres with C8-modified interior pore-walls for the determination of diazepam in rat plasma by LC-MS.[J].Xiaodan Liu;Yingjia Yu;Yan Li;Suli Ning;Tingting Liu;Fajie Li;Gengli Duan.Talanta.2012,

[4]

Multi-class determination of around 50 pharmaceuticals; including 26 antibiotics; in environmental and wastewater samples by ultra-high performance liquid chromatography–tandem mass spectrometry.[J].Emma Gracia-Lor;Juan V. Sancho;Félix Hernández.Journal of Chromatography A.2011, 16

[5]

Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography–positive electrospray ionisation tandem mass spectrometry.[J].David R. Baker;Barbara Kasprzyk-Hordern.Journal of Chromatography A.2011, 12

[6]

Occurrence; partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment.[J].Aleksandra Jelic;Meritxell Gros;Antoni Ginebreda;Raquel Cespedes-Sánchez;Francesc Ventura;Mira Petrovic;Damia Barcelo.Water Research.2010, 3

[7]

Norfluoxetine Induces Spawning and Parturition in Estuarine and Freshwater Bivalves [J].

Fong, P. P. ;

Molnar, N. .

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2008, 81 (06) :535-538

[8]

Fate of beta blockers and psycho-active drugs in conventional wastewater treatment.[J].Arne Wick;Guido Fink;Adriano Joss;Hansruedi Siegrist;Thomas A. Ternes.Water Research.2008, 4

[9]

Effects of fluoxetine on the reproduction of two prosobranch mollusks: Potamopyrgus antipodarum and Valvata piscinalis.[J].M. Gust;T. Buronfosse;L. Giamberini;M. Ramil;R. Mons;J. Garric.Environmental Pollution.2008, 2

[10]

Occurrence, treatment, and toxicological relevance of EDCs and pharmaceuticals in water [J].

Snyder, Shane A. .

OZONE-SCIENCE & ENGINEERING, 2008, 30 (01) :65-69

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