胆汁淤积的分子机制与治疗靶点

被引：9

作者：

周学谦

陈文生

机构：

[1] 陆军军医大学第一附属医院消化内科

来源：

内科理论与实践 | 2018年 / 13卷 / 06期

关键词：

胆汁淤积; 胆汁酸; 分子机制;

D O I：

10.16138/j.1673-6087.2018.06.014

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

<正>胆汁淤积即胆汁的生成和排泌障碍导致肠道内胆汁缺乏及毒性胆汁成分在肝脏、体循环中聚集的病理生理过程[1-3]。主要临床表现有黄疸、瘙痒和乏力等。实验室检查可出现血清胆红素、碱性磷酸酶(alkaline phosphatase,ALP)和γ-谷氨酰转肽酶(gamma-glutamyltransferase,GGT)升高,发生肝细胞损伤时可有丙氨酸转氨酶(alanine transaminase,ALT)和天

引用

页码：388 / 393

页数：6

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