单纯性肥胖患者血清C反应蛋白水平的变化

被引：4

作者：

李慧

邹大进

郭品娥

机构：

[1] 第二军医大学长海医院内分泌科

[2] 长海医院实验诊断科上海

[3] 上海

来源：

第二军医大学学报 | 2003年 / 11期

关键词：

C反应蛋白; 肥胖; 胰岛素抵抗;

D O I：

10.16781/j.0258-879x.2003.11.043

中图分类号：

R589.2 [脂肪代谢障碍];

学科分类号：

1002 ; 100201 ;

摘要：

为研究血清高敏C反应蛋白(high sensitivity CRP,hs-CRP)水平与肥胖及胰岛素抵抗的关系,采用乳胶增强速率免疫散射比浊法测定31例单纯性肥胖患者及30例正常人血清高敏C反应蛋白水平。结果显示,单纯肥胖组和体质量正常组血清CRP水平[中位数(四分位距)]分别为2.78(1.27-4.67)和0.62(0.32-2.32)mg/L,单纯肥胖组明显高于正常组(P<0.01)。血清CRP与体质量指数(BMI)、胰岛素敏感性简易参数(HOMA-IR)、空腹胰岛素(FINS)及空腹血糖(FPG)分别呈正相关(r=0.443,0.454,0.406及0.306,P<0.01),与腰围和脂肪百分比也呈正相关(P<0.01)。提示单纯性肥胖患者血清CRP水平较正常人升高;血清CRP与胰岛素抵抗密切相关,慢性炎症参与了胰岛素抵抗的发生和发展。

引用

页码：1272 / 1273

页数：2

共 7 条

[1]

C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Yudkin JS,Stehouwer CDA,Emeis JJ,et al. Arteriosclerosis . 1999

[2]

Diabetes[P]. 英国专利:GB201117172D0,2011-11-16

[3]

Body mass index as a measure of body fatness: age and sex-specific prediction formulas. Deurenberg P,Weststrate JA,Seidell JC,et al. British Journal of Nutrition . 1991

[4]

Body mass index, diabetes, and C-reactive protein among US adults. Ford ES. Diabetes Care . 1999

[5]

Elevated C-reactive protein levels in overweight and obese adults. Visser M,Bouter LM,McQuillan GM,et al. Journal of the American Medical Association, The . 1999

[6]

Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS. Festa A,D’Agostino R Jr,Howard G,et al. Circulation . 2000

[7]

Association between C-reactive protein and features of the metabolic syndrome: a population-based study. Frohlich M,Imhof A,Berg G,et al. Diabetes Care . 2000

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