切割球囊成形术与经皮腔内β-射线放射疗法联合治疗冠状动脉支架内再狭窄

被引：12

作者：

樊冰

葛均波

von Birgelen C

钱菊英

王齐兵

葛雷

陈灏珠

Erbel R

机构：

[1] 复旦大学附属中山医院上海市心血管病研究所心内科,复旦大学附属中山医院上海市心血管病研究所心内科,德国埃森大学心脏中心,复旦大学附属中山医院上海市心血管病研究所心内科,复旦大学附属中山医院上海市心血管病研究所心内科,复旦大学附属中山医院上海市心血管病研究所心内科,复旦大学附属中山医院上海市心血管病研究所心内科,德国埃森大学心脏中心上海,上海,上海,上海,上海,上海

来源：

中华心血管病杂志 | 2004年 / 05期

关键词：

冠状动脉疾病; 冠状动脉再狭窄; 近距离放射疗法; 血管成形术;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

摘要：

目的　观察切割球囊成形术 (CBA)与经皮冠状动脉 (冠脉 )内 β 射线放射疗法 (β 放疗 )联合治疗支架内再狭窄 (ISR)的疗效及其安全性。方法　冠脉内支架置入术后ISR >70 %的患者2 95例 ,男性 2 0 5例 ,女性 90例 ,平均年龄 (5 9 76± 10 83)岁 ,其中 112例均行CBA联合 β 放疗作为β 放疗组 (n =112 ) ,183例单独采用CBA(89例 )或普通球囊扩张成形术 (94例 )为对照组 (n =183)。弥漫性长病变ISR者回撤 β 放疗导管分段照射。所有患者术前、术后即刻及术后随访期行冠脉造影 ,随访靶血管血运重建 (TVR)和主要不良心血管事件 (MACE)发生率。结果　两组患者的术前及术后即刻冠脉造影结果差异无显著性。随访期 (6 3± 1 6 )月 β 放疗组的最小管腔直径大于对照组 ,管腔直径狭窄百分比小于对照组 ,P <0 0 5。β 放疗组与对照组的心绞痛、心肌梗死及病死率相似(心绞痛为 10 %比 17% ,心肌梗死为 1%比 2 % ,病死率为 0 %比 2 % ) ,但 β 放疗组的TVR和MACE明显低于对照组 (TVR为 5 %比 16 % ,MACE为 11%比 2 1% ,P <0 0 5 )。β 放疗组 2 8例 (2 5 % )弥漫性长病变ISR ,分段照射后随访TVR和MACE无增加。结论　冠脉内 β 放疗和CBA相结合治疗ISR安全、有效 ,TVR和MACE明显降低。采用回撤 β 放疗导管

引用

页码：5 / 8

页数：4

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