西地那非衍生物的电喷雾离子阱质谱研究

被引:8
作者
邢杰
孙璐
钟大放
机构
[1] 沈阳药科大学药物代谢与药物动力学实验室
[2] 沈阳药科大学药物代谢与药物动力学实验室 辽宁 沈阳 
[3] 辽宁 沈阳 
关键词
西地那非衍生物; 电喷雾离子阱质谱; 裂解途径;
D O I
暂无
中图分类号
O657.63 [质谱分析];
学科分类号
摘要
采用电喷雾离子阱质谱法对4种西地那非衍生物进行了质谱研究,获得了它们的结构碎片信息,通过比较它们的异同对其质谱裂解途径进行解析,发现它们的(+)ESI-MS2质谱生成磺酰基S-C键和S-N键断裂、亚甲氧基C-O键断裂以及磺酰基重排后C-S键断裂的碎片,基峰为亚甲氧基C-O键断裂产生,其(+)ESI-MS3质谱生成脱NH3、脱CO、脱NH=C=O以及异环开裂碎片,这些特征可用于阐明西地那非衍生物及其结构类似物的结构。
引用
收藏
页码:1 / 6
页数:6
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