Toll样受体在非酒精性脂肪性肝病发生发展中的作用

被引:11
作者
陈杰 [1 ]
张晶 [1 ]
何秋水 [2 ]
机构
[1] 首都医科大学附属北京佑安医院中毒性肝病科
[2] 首都医科大学病原微生物系
关键词
脂肪肝; Toll样受体; 综述;
D O I
暂无
中图分类号
R575.5 [肝代谢障碍];
学科分类号
100201 [内科学];
摘要
目前非酒精性脂肪性肝病(NAFLD)的发病尚不明确。有多项研究表明Toll样受体参与了NAFLD,特别是非酒精性脂肪性肝炎的发生和发展。简述了Toll样受体与炎症因素、Toll样受体与游离脂肪酸间的相互作用、Toll样受体基因多态性3个方面的进展,介绍了Toll样受体在NAFLD发病中的作用。
引用
收藏
页码:1153 / 1155
页数:3
相关论文
共 13 条
[1]
非酒精性脂肪性肝病诊治进展 [J].
郑盛 ;
唐映梅 .
中国全科医学, 2013, 16 (02) :117-119
[2]
非酒精性脂肪性肝病诊疗指南 [J].
范建高 .
临床肝胆病杂志, 2010, (02) :120-124
[3]
Small intestinal bacteria overgrowth decreases small intestinalmotility in the NASH rats[J] Wan-Chun Wu; Wei Zhao; Sheng Li; Department of Gastro-enterology; Yijishan Hospital; Wuhu 241000; Anhui Province; China World Journal of Gastroenterology 2008,
[4]
Expression of toll‐like receptors 1–5 but not TLR 6–10 is elevated in livers of patients with non‐alcoholic fatty liver disease[J] Giridhar Kanuri;Ruth Ladurner;Julia Skibovskaya;Astrid Spruss;Alfred K?nigsrainer;Stephan C. Bischoff;Ina Bergheim Liver Int 2015,
[5]
Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease[J] Miura Kouichi;Seki Ekihiro;Ohnishi Hirohide;Brenner David A. Gastroenterology Research and Practice 2011,
[6]
Current Views of Toll-Like Receptor Signaling Pathways[J] Masahiro Yamamoto;Kiyoshi Takeda;Ekihiro Seki Gastroenterology Research and Practice 2010,
[7]
Pattern Recognition Receptors and Inflammation[J] Osamu Takeuchi;Shizuo Akira Cell 2010,
[8]
Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice[J] Kouichi Miura;Yuzo Kodama;Sayaka Inokuchi;Bernd Schnabl;Tomonori Aoyama;Hirohide Ohnishi;Jerrold M. Olefsky;David A. Brenner;Ekihiro Seki Gastroenterology 2010,
[9]
Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non‐alcoholic steatohepatitis[J] AshkanFarhadi;SushamaGundlapalli;MalihaShaikh;ConstantineFrantzides;LauraHarrell;Mary M.Kwasny;AliKeshavarzian Liver International 2008,
[10]
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis[J] Chantal A. Rivera;Patrick Adegboyega;Nico van Rooijen;Arlene Tagalicud;Monique Allman;Matthew Wallace Journal of Hepatology 2007,