他汀类药物对骨形成影响的研究进展

被引：8

作者：

刘晓宁

张柳

机构：

[1] 华北煤炭医学院骨科

来源：

中国骨质疏松杂志 | 2008年 / 05期

关键词：

他汀类药物; 骨形成;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

他汀类药物除了可以降低血脂水平,还展现出了很多独立于降低血脂之外的其他作用。1999年Mundy等首先发现他汀类药物有促骨形成作用,其可以作为促骨形成的潜在药物而被广泛关注。随后很多学者都对他汀类药物对骨代谢的影响进行了大量的实验研究,虽然多数的研究结果支持辛伐他汀有促进骨形成和抑制骨吸收的作用,但也有部分实验未得出相同结论。为进一步研究他汀类药物在分子水平对骨代谢影响的具体作用机制,尽早研制出对骨骼具有显著作用的他汀类药物以及给药方式,是他汀类药物能否最终用于临床,治疗骨质疏松症及其他骨代谢疾病、促进骨折愈合的关键。

引用

收藏

页码：367 / 370

页数：4

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