疫苗诱导机体免疫应答机制研究

被引：5

作者：

吴星

邵杰

张军楠

梁争论

机构：

[1] 中国食品药品检定研究院

来源：

微生物学免疫学进展 | 2013年 / 41卷 / 05期

关键词：

疫苗; 免疫机制; 天然免疫; Toll样受体(TLRs);

D O I：

10.13309/j.cnki.pmi.2013.05.014

中图分类号：

R392.1 [免疫生物学];

学科分类号：

100102 ;

摘要：

人类接种疫苗已有200多年的历史,疫苗的应用使得历史上流行的多种传染病得以消灭或控制,挽救了无数人的生命。疫苗免疫机制是全世界疫苗研究者亟待解决的问题。对疫苗免疫机制的一些新认识,极大地促进了疫苗研发。对疫苗天然免疫机制的揭示,在疫苗株的筛选、疫苗免疫效果预测等方面展现了巨大的应用价值。某些疫苗在接种后存在的低应答与无应答现象,在对其免疫机制的探索中得到了解释。此外,对疫苗佐剂免疫机制的揭示,加速了新型疫苗佐剂的研发与应用。对疫苗免疫机制研究中的一些新进展进行了综述。

引用

页码：47 / 50

页数：4

共 9 条

[1]

Immunogenomics and systems biology of vaccines[J] . LuigiBuonaguro,BaliPulendran. Immunological Reviews . 2010 (1)

[2]

Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine[J] . Jie Chen,Zhenglun Liang,Fengmin Lu,Xin Fang,Shuang Liu,Ying Zeng,Fengcai Zhu,Xiangmei Chen,Tao Shen,Jie Li,Hui Zhuang. Vaccine . 2010 (4)

[3]

Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes[J] . Inna G. Ovsyannikova,Neelam Dhiman,Iana H. Haralambieva,Robert A. Vierkant,Megan M. O’Byrne,Robert M. Jacobson,Gregory A. Poland. Human Genetics . 2010 (2)

[4]

Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: Preliminary results[J] . Neelam Dhiman,Inna G. Ovsyannikova,Robert A. Vierkant,Jenna E. Ryan,V. Shane Pankratz,Robert M. Jacobson,Gregory A. Poland. Vaccine . 2008 (14)

[5] TLR signaling [J].

Kawai, Taro ;

Akira, Shizuo .

SEMINARS IN IMMUNOLOGY, 2007, 19 (01) :24-32

[6]

GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large[J] . Bruce Beutler,Zhengfan Jiang,Philippe Georgel,Karine Crozat,Ben Croker,Sophie Rutschmann,Xin Du,Kasper Hoebe. Annual Review of Immunology . 2006

[7]

The Immune Response to BCG Vaccination of Newborns[J] . WILLEM A.HANEKOM. Annals of the New York Academy of Sciences . 2006 (1)

[8] Interaction of papillomavirus virus-like particles with human myeloid antigen-presenting cells [J].

Lenz, P ;

Thompson, CD ;

Day, PM ;

Bacot, SM ;

Lowy, DR ;

Schiller, JT .

CLINICAL IMMUNOLOGY, 2003, 106 (03) :231-237

[9]

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome .2 Mirjam Kool,Virginie Pétrilli,Thibaut De Smedt,Aline Rolaz,Hamida Hammad,Menno van Nimwegen,Ingrid M. Bergen,Rosa Castillo,Bart N. Lambrecht,Jürg Tscho. J. Immunol . 2008

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