糖皮质激素诱导胰岛素抵抗的分子机制

被引：8

作者：

王丽静

刘礼斌

机构：

[1] 福建医科大学附属协和医院内分泌科福建省内分泌研究所

来源：

国际内分泌代谢杂志 | 2007年 / 06期

关键词：

糖皮质激素; 胰岛素抵抗; 脂肪细胞因子;

D O I：

暂无

中图分类号：

R587 [胰岛疾病];

学科分类号：

100201 [内科学];

摘要：

糖皮质激素是体内重要的胰岛素拮抗激素,可诱导胰岛素抵抗。糖皮质激素可以干扰骨骼肌细胞的葡萄糖摄取和利用,抑制脂肪组织中葡萄糖转运蛋白(GLUT)-4的胞内分布及糖转运活性从而抑制糖摄取。并可通过调节脂肪细胞因子如脂联素、抵抗素、瘦素、内脏脂肪素的分泌,影响胰岛素的敏感性。此外,糖皮质激素还可抑制胰岛β细胞功能,使胰岛素分泌减少,并触发胰岛细胞凋亡。

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