THE EFFECT OF LIGUSTRAZINE ON NEUROGENESIS IN CORTEX AFTER FOCAL CEREBRAL ISCHEMIA IN RATS

被引：1

作者：

邱芬 ^{[1
]}

刘勇 ^{[2
]}

张蓬勃 ^{[2
]}

康前雁 ^{[2
]}

田英芳 ^{[2
]}

陈新林 ^{[2
]}

赵建军 ^{[2
]}

祁存芳 ^{[2
]}

机构：

[1] Editorial Board of Journal of Xian Jiaotong University(Medical Sciences)

[2] Research Center for Neuroscience,Department of Human Anatomy,Histology and Embryology,Xi'an Jiaotong University School of Medicine,Xi'an 710061,China

来源：

Academic Journal of Xi'an Jiaotong University | 2006年 / 01期

关键词：

ligustrazine; cerebral ischemia; neurogenesis; cortex; penumbra;

D O I：

暂无

中图分类号：

R651 [头部及神经外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective To explore the effect of Ligustrazine on neurogenesis in cortex after focal cerebral ischemia in rats. Methods Focal cerebral ischemia was induced by left middle cerebral artery occlusion with a suture. Two hours later, injection of Ligustrazine (80mg/kg, 1 time/d) was performed peritoneally. Four hours after the ischemia, 5-bromodeoxyuridine (BrdU) (50mg/kg, 1 time/d) was injected peritoneally. At 7d, 14d and 21d after ischemia, BrdU positive cells in the cortex were observed by immunohistochemical staining. Results In ischemic model group, at 7 day, sparsely-distributed BrdU positive cells were observed in the Ⅱ-Ⅵ layers of the ipsilateral cortex, with a band-like distribution in ischemic penumbra. With the prolongation of ischemia, the number of BrdU positive cells increased. In Ligustrazine group, BrdU positive cells were also observed in the Ⅱ-Ⅵ layers of the cortex, with an intense distribution in ischemic penumbra. The numbers of BrdU positive cells at 7d, 14d and 21d were more than those in ischemic model group respectively. Conclusion Ligustrazine increases the proliferated cells in cortex after focal cerebral ischemia in rats. The results suggest that it may be useful for promoting self-repair after ischemia.

引用

页码：68 / 72

页数：5