低氧诱导因子-1α参与骨发育及骨代谢调控的研究进展

被引：18

作者：

邵进

张岩

王治

杨铁毅

机构：

[1] 上海市浦东新区公利医院骨科

来源：

中国骨质疏松杂志 | 2015年 / 21卷 / 03期

基金：

上海市自然科学基金;

关键词：

HIF-1; OPG; Wnt信号通路; 骨发育; 骨代谢;

D O I：

暂无

中图分类号：

R68 [骨科学（运动系疾病、矫形外科学）];

学科分类号：

100220 [骨科学];

摘要：

低氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)是组织细胞在低氧状态下激活相应基因转录的核心调节因子之一,在骨发育和代谢过程中起到非常重要的作用。通过敲除Vhl基因高表达HIF-1α可以促进血管和骨组织的生成,但这一过程的分子机制依然不明确。目前已知HIF-1α在骨的发育过程中可以调节多种蛋白因子和信号通路,如血管内皮生长因子(vascular endothelial growth factor,VEGF)和经典Wnt信号通路,而这些蛋白因子和信号通路大多能对细胞的分化、增殖及功能进行调节。本文综述骨组织发育和代谢过程中HIF-1α、Wnt信号通路、骨保护素(osteoprotegerin,OPG)等所起的作用以及它们之间的联系,从而进一步探讨HIF-1α在骨发育及骨代谢调控中的机制。

引用

页码：349 / 355

页数：7

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