溃疡性结肠炎患者血清IL-1β和IL-18的表达及临床意义

被引：22

作者：

唐月华

王小平

机构：

[1] 江苏省南京市高淳人民医院消化科

来源：

河北医药 | 2015年 / 37卷 / 10期

关键词：

结肠炎; 溃疡性; 代谢; 白介素-1β; 白介素-18;

D O I：

暂无

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

目的检测溃疡性结肠炎(ulcerative colitis,UC)患者血清白介素-1β(IL-1β)和白介素(IL-18)的变化,探讨其在UC发生发展过程中的作用。方法活动期UC患者42例,缓解期UC患者20例和正常对照组10例。采用酶联免疫吸附法(ELISA法)检测IL-1β和IL-18的含量,评价含量与UC患者病情轻重程度之间的关系。结果活动期UC组患者血清IL-1β和IL-18含量显著高于缓解期UC组患者和对照组(P<0.05),缓解期UC组患者与对照组比较,血清IL-1β和IL-18含量明显升高(P>0.05);血清IL-1β和IL-18含量活动期UC重型组高于中型和轻型组,与病情病情轻重程度均呈正相关(r值分别为0.623和0.588,P<0.01)。结论活动期UC患者血清IL-1β和IL-18含量显著升高,其可作为病情活动性、严重性及疗效评价的参考指标。

引用

页码：1534 / 1535

页数：2

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