糖耐量异常与血管病变及糖基化终产物

被引:7
作者
詹雅诗
冯烈
机构
[1] 暨南大学附属第一医院内分泌科
关键词
糖耐量异常; 血管病变; 糖基化终产物,高级; 糖尿病;
D O I
暂无
中图分类号
R587.2 [糖尿病性昏迷及其他并发症];
学科分类号
摘要
The definition of impaired glucose tolerance (IGT) was first introduced by the National Diabetes Data Group at 1979. Recently the morbidity rate of IGT is soaring. About 10%-15% of patients with IGT will progress to type 2 diabetes mellitus (T2DM) which is approximately more than 100 times comparing with normal glucose tolerance people. Angiopathy can be detected in 40% patients with newly diagnosed IGT. Advanced glycation end products (AGEs) are closely related to angiopathy. Meanwhile there is some connection between IGT and AGEs. In this review, the relationship between IGT, agiopathy and AGEs is discussed.
引用
收藏
页码:405 / 408
页数:4
相关论文
共 13 条
[1]   糖基化终产物诱导心肌细胞炎症反应的研究 [J].
胡波 ;
张晓刚 ;
曾琳琳 .
中国病理生理杂志, 2007, (12) :2341-2345
[2]   SR-AⅡ和CD36的表达水平与AGEs及糖尿病并发症的相关性研究 [J].
陈万群 ;
骆婕 ;
彭锐锐 ;
吴颜晖 ;
莫宏波 ;
冯烈 ;
李菊香 ;
刘誉 .
中国病理生理杂志, 2007, (01) :168-172
[3]   Nontraditional atherosclerotic risk factors and extent of coronary atherosclerosis in patients with combined impaired fasting glucose and impaired glucose tolerance [J].
Surdacki, Andrzej ;
Stochmal, Ewa ;
Szurkowska, Magdalena ;
Bode-Boger, Stefanie M. ;
Martens-Lobenhoffer, Jens ;
Stochmal, Anna ;
Klecha, Artur ;
Kaweeka-Jaszcz, Kalina ;
Dubiel, Jacek S. ;
Huszno, Bohdan ;
Szybinski, Zbigniew .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2007, 56 (01) :77-86
[4]   Lipid transfer protein activities in subjects with impaired glucose tolerance [J].
Julius, Ulrich ;
Jauhiainen, Matti ;
Ehnholm, Christian ;
Pietzsch, Jens .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2007, 45 (02) :237-243
[5]  
Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury[J] . Alison Goldin,Joshua A. Beckman,Ann Marie Schmidt,Mark A. Creager.Circulation . 2006 (6)
[6]   Positive association of serum levels of advanced glycation end products with thrombogenic markers in humans [J].
Enomoto, Mika ;
Adachi, Hisashi ;
Yamagishi, Sho-ichi ;
Takeuchi, Masayoshi ;
Furuki, Kumiko ;
Hino, Asuka ;
Hiratsuka, Akiko ;
Takajo, Yoshinori ;
Imaizumi, Tsutomu .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2006, 55 (07) :912-917
[7]   Impaired glucose tolerance increases stroke risk in nondiabetic patients with transient ischemic attack or minor ischemic stroke [J].
Vermeer, Sarah E. ;
Sandee, Willemijn ;
Algra, Ale ;
Koudstaal, Peter J. ;
Kappelle, L. Jaap ;
Dippel, Diederik W. J. .
STROKE, 2006, 37 (06) :1413-1417
[8]   The AGE/RAGE/NF-κB pathway may contribute to the pathogenesis of polyneuropathy in impaired glucose tolerance (IGT) [J].
Haslbeck, KM ;
Schleicher, E ;
Bierhaus, A ;
Nawroth, P ;
Haslbeck, M ;
Neundörfer, B ;
Heuss, D .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2005, 113 (05) :288-291
[9]   Poly(ADP-ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity [J].
Szabó, C ;
Zanchi, A ;
Komjáti, K ;
Pacher, P ;
Krolewski, AS ;
Quist, WC ;
LoGerfo, FW ;
Horton, ES ;
Veves, A .
CIRCULATION, 2002, 106 (21) :2680-2686
[10]  
Diabetes[P]. 英国专利:GB201117172D0,2011-11-16