慢性乙型肝炎患者肝组织中维生素D受体表达与肝损伤的相关性附视频

被引：6

作者：

袁利超

马安林

机构：

[1] 中日友好医院感染疾病科

来源：

中日友好医院学报 | 2017年 / 02期

关键词：

慢性乙型肝炎; 维生素D受体; CYP2R1; CYP27A1;

D O I：

暂无

中图分类号：

R512.62 []; R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

目的:研究慢性乙型肝炎患者肝组织维生素D受体(VDR)的表达及其下调机制。方法:选取60例慢性乙型肝炎患者作为研究组,按肝组织学结果分成3组,每组均20例。F1组:肝纤维化分级为1级;F2组:肝纤维化分级为2级;F3组:肝纤维化分级为3级。对照组选取20例因其他疾病行肝脏手术切除的标本。所有病例均检测HBVDNA和生化学指标,免疫组化染色检测VDR、CYP2R1、CYP27A1的表达。结果:对照组与慢性乙肝组比较,VDR在胆管上皮细胞的表达差异无统计学意义(P>0.05)。VDR、CYP2R1和CYP27A1在肝细胞的表达慢性乙肝组比对照组显著减弱(P<0.05)。在慢性乙肝组CYP2R1和CYP27A1相比VDR的表达显著减弱(P<0.05)。在F1、F2、F3组间3种受体的表达无统计学差异(P>0.05)。在慢性乙肝组VDR的表达与CYP2R1的表达呈显著正相关(P<0.05),与HBVDNA水平呈负相关(P<0.05)。结论:VDR在慢性乙肝患者肝细胞的表达与对照组相比显著下降,表达强弱与CYP2R1呈明显的正相关,与HBVDNA呈负相关。

引用

页码：98 / 101

页数：4

共 17 条

[1]

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[2]

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