大黄素抗炎作用及相关机制研究进展

被引：76

作者：

高红刚 ^{[1
]}

周菊华 ^{[2
]}

机构：

[1] 济宁医学院药学院

[2] 鲁东大学生命科学学院

来源：

济宁医学院学报 | 2016年 / 39卷 / 05期

关键词：

大黄素; 抗炎作用; 机制;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

大黄素为蒽醌类衍生物,具有利尿、舒张血管、抗菌、抗病毒、抗炎和抗癌等药理活性。关于大黄素抗炎作用的研究报道日益增多,体内和体外试验已证明大黄素对多种炎症具有调节作用。其作用机制可能为大黄素与许多炎症过程中的重要分子和炎性细胞(NF-κB、PPAR、inflammasome、SDF-1和巨噬细胞等)相互作用,通过多种途径调节炎症反应,避免过度炎症对组织的损伤。本文对近5年来大黄素抑制多种炎症的活性和相关机制进行综述,为大黄素抗炎机制的阐明及相关药物的研发提供参考。

引用

页码：348 / 352

页数：5

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