人类精子RNA生殖功能研究进展

被引：4

作者：

牛志宏 ^{[1
,2
]}

施惠娟 ^{[2
]}

张慧琴 ^{[2
]}

机构：

[1] 复旦大学医学院

[2] 上海市计划生育科研所

来源：

中华男科学杂志 | 2009年 / 03期

关键词：

精子RNA; 精子活力; 受精; 早胚发育;

D O I：

10.13263/j.cnki.nja.2009.03.008

中图分类号：

R321.2 [受精、卵裂];

学科分类号：

摘要：

人类成熟精子中RNA的存在已经被证实,主要包括mRNA和部分小RNA家族成员。随着研究深入,发现精子mRNA表达差异,与精子活力和男性生育功能相关。而部分精子中特异存在的mRNA和小RNA在精卵融合和早期胚胎发育调控中有重要作用。已经获得的结果提示精源性RNA的表达具有个体差异性,并且是胚胎发育所必需的。对精子RNA功能的深入研究将会对男性不育、人类辅助生育技术以及核移植技术等相关领域产生推动作用。

引用

页码：256 / 260

页数：5

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