病毒载量动态检测在乙型肝炎治疗和研究中的意义

被引：21

作者：

洪卫国

王福生

陈菊梅

机构：

[1] 中国人民解放军第三○二医院传染病研究所全军艾滋病和病毒性肝炎防治重点实验室,中国人民解放军第三○二医院传染病研究所全军艾滋病和病毒性肝炎防治重点实验室,中国人民解放军第三○二医院传染病研究所全军艾滋病和病毒性肝炎防治重点实验室北京,北京,北京

来源：

中华肝脏病杂志 | 2003年 / 01期

关键词：

肝炎,乙型; 病毒载量; 动态检测; 耐药性; 嗜向性; 病毒感染动力学;

D O I：

暂无

中图分类号：

R512.62 [];

学科分类号：

摘要：

<正> 目前对乙型肝炎病毒(hepatitis B virus,HBV)与人体基因作用动态过程的具体细节还不清楚。但随着核酸定量技术的发展,已经有可能同时监测病毒在体内复制、表达的过程和人体基因表达谱的变化[1]。现就实时、动态、定量检测病毒DNA在认识HBV的体内过程和乙型肝炎致病进程中的作

引用

页数：3

共 10 条

[1]

Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B [J].

Da Silva, LC ;

Pinho, JRR ;

Sitnik, R ;

Da Fonseca, LEP ;

Carrilho, FJ .

JOURNAL OF GASTROENTEROLOGY, 2001, 36 (07) :476-485

[2]

Hepatitis B virus variants in patients receiving lamivudine treatment with breakthrough hepatitis evaluated by serial viral loads and full-length viral sequences [J].

Liu, CJ ;

Chen, PJ ;

Lai, MY ;

Kao, JH ;

Chen, DS .

HEPATOLOGY, 2001, 34 (03) :583-589

[3]

High incidence of hepatitis B infections among chronic hepatitis cases of unknown aetiology [J].

Chemin, I ;

Zoulim, F ;

Merle, P ;

Arkhis, A ;

Chevallier, M ;

Kay, A ;

Cova, L ;

Chevallier, P ;

Mandrand, B ;

Trépo, C .

JOURNAL OF HEPATOLOGY, 2001, 34 (03) :447-454

[4]

A rapid real-time quantitative polymerase chain reaction for hepatitis B virus.[J].K. Brechtbuehl;S.A. Whalley;G.M. Dusheiko;N.A. Saunders.Journal of Virological Methods.2001, 1

[5]

Correlation between serum transaminase activity and virus load among patients with chronic liver disease type B [J].

Sakugawa, H ;

Nakasone, H ;

Nakayoshi, T ;

Kawakami, Y ;

Yamashiro, T ;

Maeshiro, T ;

Kinjo, F ;

Saito, A .

HEPATOLOGY RESEARCH, 2001, 21 (02) :159-168

[6]

Serological and molecular testing in viral hepatitis: An update [J].

Weston, SR ;

Martin, P .

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2001, 15 (03) :177-184

[7]

Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation [J].

Delaney, WE ;

Locarnini, S ;

Shaw, T .

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 2001, 12 (01) :1-35

[8]

The presence of high amounts of HBV-DNA in serum is associated with suppressed costimulatory effects of interleukin 12 on HBV-induced immune response [J].

Schlaak, JF ;

Tully, G ;

Löhr, HF ;

Gerken, G ;

zum Büschenfelde, KHM .

JOURNAL OF HEPATOLOGY, 1999, 30 (03) :353-358

[9]

The role of HBV DNA quantitative PCR in monitoring the response to interferon treatment in chronic hepatitis B virus infection [J].

Nagata, I ;

Colucci, G ;

Gregorio, GV ;

Cheeseman, P ;

Williams, R ;

Mieli-Vergani, G ;

Vergani, D .

JOURNAL OF HEPATOLOGY, 1999, 30 (06) :965-969

[10]

HBV viral load within subpopulations of peripheral blood mononuclear cells in HBV infection using limiting dilution PCR.[J].Martin Trippler;Karl-Herrmann Meyer zum Büschenfelde;Guido Gerken.Journal of Virological Methods.1999, 1

← 1 →