金属基质蛋白酶及抑制剂与乳腺癌研究进展

被引:3
作者
陈建生
孙治君
机构
[1] 重庆医科大学附属第一医院普外科
关键词
MMP-2; MMP-9; TIMP-1; 乳腺癌;
D O I
暂无
中图分类号
R737.9 [乳腺肿瘤];
学科分类号
100214 ;
摘要
金属基质蛋白酶(MMP)及抑制剂(TIMP)与细胞外基质(ECM)的降解密切相关,而ECM的降解和乳腺癌的浸润,转移相关。查阅国外相关文献发现乳腺癌患者中TIMP-1低水平表达,但有时也较高水平表达,MMP-2,MMP-9水平明显高于正常人,并且可能与术后的愈合相关。所以对于MMPs,TIMPs的进一步研究有望为乳腺癌治疗提供新的方向。
引用
收藏
页码:365 / 367
页数:3
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