转化生长因子-β对基质金属蛋白酶及其组织抑制因子调控的研究进展

被引:16
作者
林海燕
王红梅
祝诚
机构
[1] 中国科学院动物研究所
[2] 中国科学院动物研究所 计划生育生殖生物学国家重点实验室
[3] 北京
[4] 计划生育生殖生物学国家重点实验室
关键词
基质金属蛋白酶; 基质金属蛋白酶组织抑制因子; 转化生长因子-β; Smad通路; MAPK信号通路; 激活蛋白-1;
D O I
暂无
中图分类号
Q75 [分子遗传学];
学科分类号
071007 ;
摘要
基质金属蛋白酶 (MMPs)及其组织抑制因子 (TIMPs)参与调控胞外基质 (ECM)的降解与重建 ,二者的协同作用以及表达的动态平衡保证组织的生理 /病理形态结构建成 ,并完成生长、分化、维持、降解的往复周期 .转化生长因子 β (TGF β)通过对MMPs和TIMPs家族成员因细胞类型而异的基因表达调控作用 ,表现出调节ECM重建的生物学效应 .TGF β可通过激活Smad通路、促分裂原活化蛋白激酶 (MAPK)通路 ,以及刺激激活蛋白 1(AP 1)复合体的形成 ,完成对MMPs和TIMPs基因表达的调控功能 .
引用
收藏
页码:7 / 12
页数:6
相关论文
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