类风湿关节炎患者滑膜树突状细胞的研究

被引：7

作者：

郑毅

陆江阳

尹义存

孙笑非

黄火高

杨毅

机构：

[1] 海军总医院内分泌风湿科

[2] 解放军第医院病理科

来源：

中华风湿病学杂志 | 2003年 / 01期

关键词：

关节炎,类风湿; 树突细胞; 抗原提呈细胞; 自身免疫;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

摘要：

目的　探讨滑膜树突状细胞在类风湿关节炎 (RA)中的作用。方法　采用免疫组织化学方法观察 2 5例RA滑膜中HLA DR抗原阳性表达细胞、S 10 0阳性CD1a阳性的树突状细胞(DC)的多少和分布情况。结果　 2 3例RA滑膜细胞HLA DR表达阳性 ,19例S 10 0表达阳性 ,16例CD1a表达阳性 ,其阳性例数的百分率均高于对照组。RA滑膜中HLA DR、S 10 0和CD1a标记阳性细胞数均明显高于对照组 ,其差异有非常显著意义 (P <0 0 1)。结论　RA滑膜中DC和被激活的DC及HLA DR阳性细胞的存在和增多可能在RA病变局部递呈自身抗原的过程中起重要的作用 ,是RA自身免疫异常的重要的始发因素

引用

页码：22 / 25+66 +66

页数：5

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