黄芩汤抗TNBS诱导的小鼠溃疡性结肠炎活性研究

被引：14

作者：

巢蕾 ^{[1
]}

曹雨诞 ^{[2
]}

陈佩东 ^{[2
]}

机构：

[1] 江苏省中医院药剂科

[2] 南京中医药大学药学院

来源：

安徽医药 | 2015年 / 19卷 / 12期

关键词：

溃疡性结肠炎; 黄芩汤; 髓过氧化物酶; 液质联用; 2,4,6-三硝基苯磺酸钠;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的研究黄芩汤水煎液中主要成分及对2,4,6-三硝基苯磺酸钠(TNBS)造模balb/c小鼠的溃疡性结肠炎的作用。方法 HPLC-MS法分析水煎液成分。雄性balb/c小鼠随机分为空白对照组,TNBS模型组,柳氮磺嘧啶阳性对照组(500 mg·kg-1),黄芩汤水煎液1,2,4 g·kg-1治疗组。TNBS造模7 d后,研究各组小鼠的结肠病理评分、微观评分、体质量、小鼠结肠长度和血清髓过氧化物酶(MPO)。结果与标准品对照,黄芩汤水煎液中含有复方中主要成分,黄芩汤水煎液可使TNBS造模balb/c小鼠的体质量明显增加,改善身体的一般状况和小鼠结肠黏膜的损伤,下调MPO。结论黄芩汤水煎液中含有各药物的主要成分,对TNBS诱导的小鼠溃疡性结肠炎具有较好的治疗作用。

引用

页码：2292 / 2295

页数：4

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