肝窦内皮细胞在肝脏疾病中的作用

被引：27

作者：

张晨曦 ^{[1
,2
]}

卞勉励 ^{[1
,2
]}

陈星燃 ^{[1
,2
]}

赵士峰 ^{[1
,2
]}

金欢欢 ^{[1
,2
]}

陈琴 ^{[1
,2
]}

张峰 ^{[1
,2
,3
]}

郑仕中 ^{[1
,2
,3
]}

机构：

[1] 南京中医药大学药学院

[2] 南京中医药大学

[3] 江苏省中药药效与安全性评价重点实验室

来源：

中国药理学通报 | 2017年 / 33卷 / 02期

关键词：

肝窦内皮细胞; 肝窦毛细血管化; 非酒精性脂肪肝; 酒精性脂肪肝; 肝细胞性肝癌; 肝再生; 肝纤维化;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

肝窦内皮细胞(liver sinusoidal endothelial cells,LSECs)作为肝脏中比例最高的非实质细胞,其窗孔结构和高内吞清除能力在肝脏生理病理过程中发挥不可或缺的作用。LSECs主要通过发挥抗炎、内吞、分泌促血管生成信号分子和维持HSCs表型等作用,参与调控非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)、酒精性脂肪肝(alcoholic fatty liver,AFL)、肝细胞性肝癌(hepatocellular carcinoma,HCC)、肝再生、肝纤维化等肝脏病理过程。该文就LSECs正常生理功能及其在各种病理状态下发挥的不同作用作一综述,旨在通过靶向LSECs为治疗肝脏疾病提供新的观点。

引用

页码：149 / 153

页数：5

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