氯吡格雷预防动脉粥样硬化血栓形成的作用及临床意义——CAPRIE、CLASSICS和CURE研究

被引:6
作者
李勇
机构
[1] 复旦大学医学院附属华山医院心内科
关键词
氯吡格雷; 动脉粥样硬化; 急性冠脉综合征;
D O I
暂无
中图分类号
R543 [血管疾病];
学科分类号
1002 ; 100201 ;
摘要
近期进行的一系列大型临床研究(CAPRlE研究、CLASSICS研究和CURE研究)证实,氯吡格雷在血栓事件高危患者群体中具有优良的安全性和耐受性;在冠脉支架植入患者中氯吡格雷联合阿司匹林的安全性和耐受性优于噻氯匹定联合阿司匹林;而对于急性冠脉综合征患者应在标准治疗的基础上,及早开始并长期应用氯吡格雷。
引用
收藏
页码:234 / 236+240 +240
页数:4
相关论文
共 8 条
[1]  
Unstable angina-report from a Canadian expert roundtable. Cairns J,Theroux P,Armstrong P,et al. Canadian Journal of Cardiology . 1996
[2]  
The ENACT study: a pan-European survey of acute coronary syndromes. Fox KA,Cokkinos DV,Deckers J,et al. European Heart Journal . 2000
[3]  
The pathogenesis of coronary artery disease and the acute coronary syndromes. Fuster V,Badimon L,Badimon JJ,et al. The New England Journal of Medicine . 2000
[4]  
Clopidogrel: a review of its use in the prevention of atherothrombosis. Jarvis B,Simpson K. Drugs . 2000
[5]  
The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme. Mehta SR,Yusuf S. European Heart Journal . 2000
[6]  
Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardial infarction without initial ST elevation. Yusuf S,Rather M,Rogue JT. The Lancet . 1998
[7]  
Double-blind study of the safety of Clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the Clopidogrel aspirin stent international cooperative study (CLASS. Bertrand ME,Rupprecht HJ,Urban P,et al. Circulation . 2000
[8]  
A randomised, blinded, trial of Clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. The Lancet . 1996