肠道微生态与中枢神经系统疾病的相关性

被引：58

作者：

刘萍

罗本燕

机构：

[1] 浙江大学医学院附属第一医院神经内科浙江大学医学院附属第一医院脑医学中心

来源：

中国神经精神疾病杂志 | 2016年 / 42卷 / 04期

关键词：

肠道微生态; 中枢神经系统疾病; “菌群-肠-脑”轴;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

<正>肠道菌群与其宿主相互作用相互影响的统一体称为肠道微生态(Gut microflora),是人体最大的微生态系统,其在人类健康与疾病中的重要作用已成为近年来的研究热点。近来的研究显示人体肠道微生态与肥胖的发生发展、心血管疾病、代谢综合征(如2型糖尿病)、应激、抑郁症等密切相关。蕴含着"人类第二大脑"—肠神经系统的肠道微生态系统,和与其共生的肠道菌群相互作用、相互

引用

页码：251 / 254

页数：4

共 11 条

[1]

Role of Gut Microbiota in Obesity; Type 2 Diabetes and Alzheimerμs Disease.[J].Muhammad I. Naseer;Fehmida Bibi;Mohammed H. Alqahtani;Adeel G. Chaudhary;Esam I. Azhar;Mohammad A. Kamal;Muhammad Yasir.CNS & Neurological Disorders - Drug Targets.2014, 2

[2]

A Possible Link of Gut Microbiota Alteration in Type 2 Diabetes and Alzheimerµs Disease Pathogenicity: An Update.[J].Mohammad Z. Alam;Qamre Alam;Mohammad A. Kamal;Adel M. Abuzenadah;Absarul Haque.CNS & Neurological Disorders - Drug Targets.2014, 3

[3]

Microbial view of central nervous system autoimmunity [J].

Berer, Kerstin ;

Krishnamoorthy, Gurumoorthy .

FEBS LETTERS, 2014, 588 (22) :4207-4213

[4]

Microbes and the gut-brain axis [J].

Bercik, P. ;

Collins, S. M. ;

Verdu, E. F. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2012, 24 (05) :405-413

[5]

Oral administration of probiotic bacteria, Lactobacillus casei and Bifidobacterium breve, does not exacerbate neurological symptoms in experimental autoimmune encephalomyelitis [J].

Kobayashi, Toshihide ;

Kato, Ikuo ;

Nanno, Masanobu ;

Shida, Kan ;

Shibuya, Kazumoto ;

Matsuoka, Yoshiaki ;

Onoue, Masaharu .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2010, 32 (01) :116-124

[6]

Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora [J].

Ochoa-Reparaz, Javier ;

Mielcarz, Daniel W. ;

Haque-Begum, Sakhina ;

Kasper, Lloyd H. .

GUT MICROBES, 2010, 1 (02) :103-108

[7]

Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease? [J].

Phillips, R. J. ;

Walter, G. C. ;

Wilder, S. L. ;

Baronowsky, E. A. ;

Powley, T. L. .

NEUROSCIENCE, 2008, 153 (03) :733-750

[8]

Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease [J].

Anderson, Grant ;

Noorian, All Reza ;

Taylor, Georgia ;

Anitha, Mallappa ;

Bernhard, Doug ;

Srinivasan, Shanthi ;

Greene, James G. .

EXPERIMENTAL NEUROLOGY, 2007, 207 (01) :4-12

[9]

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.[J].Heiko Braak;Rob A.I. de Vos;Jürgen Bohl;Kelly Del Tredici.Neuroscience Letters.2005, 1

[10]

Interferon-β-1b decreased matrix metalloproteinase-9 serum levels in primary progressive multiple sclerosis [J].

Yushchenko, M ;

Mäder, M ;

Elitok, E ;

Bitsch, A ;

Dressel, A ;

Tumani, H ;

Bogumil, T ;

Kitze, B ;

Poser, S ;

Weber, F .

JOURNAL OF NEUROLOGY, 2003, 250 (10) :1224-1228

← 1 2 →