心肺复苏过程中进行溶栓治疗的Meta分析

被引:24
作者
李欣
廖晓星
荆小莉
蔺际
马中富
李玉杰
机构
[1] 中山大学附属第一医院急诊科
[2] 中山大学附属第一医院急诊科 广东省广州
[3] 广东省广州
关键词
心肺复苏术; 血栓溶解疗法; 治疗学; 综合分析;
D O I
暂无
中图分类号
R459.7 [急症、急救处理];
学科分类号
100218 ;
摘要
目的根据现有临床研究评价对心肺复苏过程中进行溶栓治疗的有效性和安全性。方法从1966-01-01-2004-08-01MEDLINE光盘数据库,检索以心跳骤停后进行心肺复苏术的患者为研究对象,比较溶栓与非溶栓治疗效果的临床研究文献,并对文献结果进行Meta分析。结果共9篇临床研究文献入选。心肺复苏过程中进行溶栓治疗可以显著提高自主循环恢复率、24小时存活率、出院率并改善远期神经功能(P<0·01)。相比非溶栓治疗,溶栓治疗显著增加了严重性出血的发生率(P<0·01)。结论与非溶栓治疗比较,溶栓治疗增加了的严重性出血的发生率。但从整体而言,心肺复苏术过程中进行溶栓治疗可以显著提高患者的出院率并改善远期神经功能。
引用
收藏
页码:651 / 654
页数:4
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