铜绿假单胞菌群体感应系统及其抑制剂的研究进展

被引：11

作者：

曾莉莉

史道华

牛培广

机构：

[1] 福建省妇幼保健院药剂科

来源：

中国抗生素杂志 | 2014年 / 39卷 / 09期

关键词：

铜绿假单胞菌; 群体感应; 致病性; 耐药性; 调节因子; 群体感应抑制剂;

D O I：

10.13461/j.cnki.cja.005421

中图分类号：

R378 [病原细菌];

学科分类号：

摘要：

铜绿假单胞菌耐药严重,形成的感染严重威胁患者健康。群体感应是细菌密度依赖的群体调控行为。细菌利用可扩散的信号分子监控周围同种或异种细菌的密度,调控特定基因的适时、协同表达。群体感应系统参与调控铜绿假单胞菌的致病性和耐药性,备受关注。深入研究铜绿假单胞菌的群体感应系统,可阐明该菌的群体行为调控机制及致病机制,由此研发铜绿假单胞菌群体感应系统的抑制剂,对缓解该菌的耐药并根除其感染具有重要意义。本文就铜绿假单胞菌群体感应系统及其抑制剂的研究进展做一综述。

引用

页码：701 / 705+714 +714

页数：6

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