电流密度和pH对奥旦西酮体外离子导入的影响

被引:5
作者
丁平田
魏刚
卞生杰
郑俊民
机构
[1] 沈阳药科大学药学系!沈阳
关键词
奥旦西酮; 离子导入; 电流密度; pH;
D O I
10.14066/j.cnki.cn21-1349/r.2000.03.001
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
以小鼠全皮为渗透屏障膜 ,考察了电流密度和 pH对奥旦西酮体外离子导入的影响 .在实验电流范围内 ,药物的稳态流量与电流密度呈正比 ,但不是严格的线性关系 ;稳态流量与pH的关系图呈“S”型 ,因为pH的变化导致了药物解离度的改变
引用
收藏
页码:157 / 159
页数:3
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