冶疗偏头痛药物与5-HT受体

被引:6
作者
陈丽娟
金国章
机构
[1] 中国科学院上海药物研究所!上海,,中国科学院上海药物研究所!上海,
关键词
偏头痛; 5—HT1D受体; 舒马曲坦; 麦角胺;
D O I
10.13220/j.cnki.jipr.1995.01.006
中图分类号
R747.2 [偏头痛];
学科分类号
1002 ;
摘要
偏头痛发病部位在脑膜血管上,5-HT系统参与首要作用,多巴胶(DA)系统居其次。急性发作前期释放大量S-HT,作用于脑膜血管,使血管收缩;急性发作时,血管过度舒张,浆液外渗,形成无菌性炎症,刺激冲动从三叉神经上传,出现恶心、呕吐、头痛、怕光等神经症状。偏头痛发作时,DA系统处于超海已发作期应用5-HT1D受体激动剂和D2受体拮抗剂治疗;长期性预防发作可用5-HT2受体桔抗剂和DA受体激动剂。舒马曲坦是当今最有选择性的5-HT1D受体激动剂,适用于急性治疗。
引用
收藏
页码:20 / 24
页数:5
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