肠上皮细胞紧密连接的研究进展

被引：49

作者：

张金卫 ^{[1
]}

林汉杰 ^{[1
]}

韩凌 ^{[2
]}

机构：

[1] 广州中医药大学第二临床医学院

[2] 广州中医药大学第二附属医院

来源：

中国医药导报 | 2015年 / 12卷 / 06期

关键词：

紧密连接; 肠上皮细胞; 信号通路;

D O I：

暂无

中图分类号：

R329.2 [人体细胞学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

肠上皮细胞紧密连接(TJ)在肠道黏膜屏障中起着重要作用,其受损会导致细胞间的通透性增加,细菌、内毒素和大分子物质通过细胞旁路途径进入其他组织、器官或体循环,从而引发疾病。本文从蛋白角度和信号通路角度介绍肠上皮细胞TJ的研究进展,并进一步指出肠黏膜受到刺激后分泌大量的Zonulin蛋白,其与Zonulin受体结合,传导信号,调控TJ上Claudin、Occludin、JAM、ZOs、Cingulin等多种蛋白的表达,从而开放TJ。肿瘤坏死因子-α通过激活核转录因子κB p65/p50异源二聚体与启动子下游κB结合区域结合激活肌球蛋白轻链激酶转录启动子是TJ信号通路中较为成熟的通路。

引用

页码：160 / 163

页数：4

共 17 条

[1]

Intestinal Permeability and Its Regulation by Zonulin: Diagnostic and Therapeutic Implications [J].

Fasano, Alessio .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2012, 10 (10) :1096-1100

[2]

Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation [J].

Gilbert, Shila ;

Zhang, Rongli ;

Denson, Lee ;

Moriggl, Richard ;

Steinbrecher, Kris ;

Shroyer, Noah ;

Lin, James ;

Han, Xiaonan .

EMBO MOLECULAR MEDICINE, 2012, 4 (02) :109-124

[3]

Biochemistry of smooth muscle myosin light chain kinase [J].

Hong, Feng ;

Haldeman, Brian D. ;

Jackson, Del ;

Carter, Mike ;

Baker, Jonathan E. ;

Cremo, Christine R. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2011, 510 (02) :135-146

[4]

Dynamics and functions of tight junctions.[J].Emily Steed;Maria S. Balda;Karl Matter.Trends in Cell Biology.2009, 3

[5]

Characterization of Tightly Associated Smooth Muscle Myosin–Myosin Light-Chain Kinase–Calmodulin Complexes.[J].Feng Hong;Brian D. Haldeman;Olivia A. John;Paul D. Brewer;Yi-Ying Wu;Shaowei Ni;David P. Wilson;Michael P. Walsh;Jonathan E. Baker;Christine R. Cremo.Journal of Molecular Biology.2009, 5

[6]

Myosin phosphatase target subunit: Many roles in cell function.[J].Fumio Matsumura;David J. Hartshorne.Biochemical and Biophysical Research Communications.2007, 1

[7]

IFN-γ-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction [J].