大鼠甲状腺功能状态对心肌细胞凋亡的影响

被引：28

作者：

周泉

李志梁

王素华

陆青

机构：

[1] 解放军医院心内科!陕西西安

[2] 第一军医大学珠江医院心内科!广东广州

来源：

第四军医大学学报 | 2001年 / 15期

关键词：

大鼠; 甲状腺功能; TUNEL; 心肌细胞凋亡;

D O I：

暂无

中图分类号：

R541 [心脏疾病];

学科分类号：

1002 ; 100201 ;

摘要：

目的　了解甲状腺功能变化对心肌细胞凋亡的影响 ,探讨甲状腺功能异常影响心肌细胞凋亡的机制 .方法　建立实验性甲亢与甲减大鼠模型 (n =2 4) ,检测血清T3 ,T4及促甲状腺激素 (TSH) ,利用末端转移酶介导的缺口末端标记法 (TUNEL)检测心肌细胞凋亡 .结果　正常大鼠及甲亢大鼠未出现心肌细胞凋亡 .甲减大鼠均出现心肌细胞凋亡 ,凋亡程度左心室 >右心室 ,并与血清T3 ,T4 呈负相关 (r =- 0 .834 ,P <0 .0 0 1) ,与TSH呈正相关 (r =0 .941,P <0 .0 0 1) .结论　心肌细胞凋亡与甲状腺功能状态密切相关 ,血液中甲状腺激素参与调控心肌细胞凋亡

引用

页码：1388 / 1391

页数：4

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