Survivin在子宫内膜异位症组织中的表达及其意义

被引:2
作者
徐红
况燕
缪勇建
欧奇志
徐文生
机构
[1] 广西医科大学第一附属医院妇科,广西医科大学第一附属医院妇科,广西医科大学第一附属医院妇科,广西医科大学第一附属医院妇科,广西医科大学第一附属医院妇科南宁,南宁,南宁,南宁,南宁
关键词
子宫内膜异位症; 基因; Survivin; 免疫组织化学;
D O I
10.16190/j.cnki.45-1211/r.2005.04.019
中图分类号
R711.71 [子宫内膜异位症];
学科分类号
100211 ;
摘要
目的:探讨凋亡抑制基因Survivin与子宫内膜异位症(EM)发病的关系。方法:收集EM患者的卵巢子宫内膜异位病灶组织33份,在位内膜组织32份及非子宫内膜异位症患者的子宫内膜26份,分别测定Survivin蛋白的表达情况。结果:Survivin的表达在位内膜组高于正常对照组和异位内膜组(P<0.05)。异位内膜组高于正常对照组(P<0.05)。结论:Survivin在EM的发生中可能起着较为重要的作用。
引用
收藏
页码:532 / 533
页数:2
相关论文
共 8 条
[1]  
Apoptosis in human endometrium and endometriosis. Harada T,Kaponis A,Iwabe T,et al. Human Reproduction Update . 2004
[2]  
Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis. Gebel HM,Braun DP,Tambur A,et al. Fertility and Sterility . 1998
[3]  
Apoptosis and expression of Bcl-2and Bax in eutopic endometrium from women with endometriosis. Meresman GF,Vighi S,Buquet RA,et al. Fertility and Sterility . 2000
[4]  
Apoptosis in human endometrial and endometriotic tissues. Suganuma N,Harada M,Furuhashi M,et al. Hormone Research . 1997
[5]  
Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth. Chen J,Wu W,Tahir SK,et al. Neoplasia . 2000
[6]  
et al.survivin gene expression in endometriosis. Ueda M,Yamashita Y,Takehara M. The Journal of Clinical Endocrinology . 2002
[7]  
Expression of sur-vivin and Bcl-2 in the normal human endometrium. Konno R,Yamakawa H,Utsunomiya H,et al. Molecular Human Reproduction . 2000
[8]  
Developmentallyregulated expression of the novel cancer anti-apoptosis genesurvivin in human and mouse differentiation. Adida C,Crotty PL,McGrath J,et al. American Journal of Pathology . 1998