干扰素治疗慢性乙型肝炎43例

被引:6
作者
陆坚
杨山麦
敖飞健
周伯平
机构
[1] 深圳市东湖医院!,深圳市东湖医院!,深圳市东湖医院!,深圳市肝病研究所!
关键词
小儿; 慢性乙型肝炎; 干扰素;
D O I
暂无
中图分类号
R725.1 [小儿传染病];
学科分类号
100202 ;
摘要
探讨干扰素治疗小儿慢性乙型肝炎(CHB)的疗效、安全性及其影响因素。方法用干扰素α-2b治疗43例小儿CHB患者,并以32例患儿做为对照。结果治疗组病毒复制标志的阴转率显著高于对照组;ALT复常率近期显著高子对照组,远期则无明显差别。治疗前ALT高值、血清HBV-DNA低水平及非母婴传播为干扰素治疗的有利因素。干扰素治疗组未见严重不良反应。结论干扰素可用于小儿CHB的治疗,疗效的高低取决于适当病例的选择。
引用
收藏
页码:3 / 4
页数:2
相关论文
共 6 条
[1]  
Enzymatic amplification of hepatitis B virus DNA in serum compared with infectivity testing in chimpanzees. Urich Paul P. The Journal of Infectious Diseases . 1989
[2]  
Treatment of chronic he patitis B in children with recombinant alfa interferon.Different response according to age at infection. Bruguera M.Amat L,Garcla O.et al. Journal of Clinical Gastroenterology . 1993
[3]  
Long-term follow-up in a randomized controlled trial of recombinant alpha-interferon in Chinese pa tients with chronic hepatitis B infection. Lok A.Lai C,Wu P,et al. The Lancet . 1988
[4]  
Clearance of chronic hepatitis B virus infection in young children after alpha interferon treatment. Narkewicz MR.Smith D.Silverman A,et al. The Journal of Pediatrics . 1995
[5]  
Interferon treatment in children with chronic hepatitis B. Ruiz M M. Journal of Hepatology . 1995
[6]  
Karayiannis P·Brook G.Treatment of hepatitis B virus infection with interferon.Factors predicting response to in terferon. Thomas HC. Journal of Hepatology . 1991