慢性肾脏病非透析患者脑钠素与动脉粥样硬化及心功能的关系

被引：20

作者：

周文彦

倪兆慧

方炜

顾乐怡

王琴

牟姗

曹励欧

俞赞喆

钱家麒

机构：

[1] 上海交通大学医学院附属仁济医院肾内科

来源：

中华肾脏病杂志 | 2007年 / 03期

关键词：

利钠肽,脑; 动脉硬化; 肾透析; 慢性肾脏病; 心功能;

D O I：

暂无

中图分类号：

R686 [筋腱、韧带、滑囊疾病及损伤];

学科分类号：

100220 [骨科学];

摘要：

目的研究脑钠素(BNP)与慢性肾脏病(CKD)非透析患者动脉粥样硬化及心功能不全的关系。方法采用双抗夹心免疫荧光法检测203例CKD非透析患者与16例高血压患者对照组全血BNP水平,分析其与颈动脉超声结果、心脏彩超结果及既往心血管疾病史的关系。结果CKD非透析患者BNP水平与对照组相比显著升高[M(范围):54.40(15.10～173.00)ng/L比9.35(7.35～15.00)ng/L,P<0.01]。Spearman相关分析显示CKD患者BNP与颈动脉内膜中层厚度(IMT)、左室心肌重量指数(LVMI)等呈正相关。存在颈动脉斑块、左室肥厚或既往发生过心血管事件的患者血BNP水平显著增高。多元回归分析显示LVMI、既往心血管事件均是影响BNP水平的独立因素。结论CKD非透析患者BNP水平和动脉粥样硬化性疾病、左室肥厚及心功能不全相关,提示BNP水平可作为一项评价CKD非透析患者心功能及动脉粥样硬化的敏感生物学指标。

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