川芎嗪逆转K562/ADM细胞多耐药性的研究

被引:19
作者
李建华
杨佩满
机构
[1] 大连医科大学附属第三医院!(辽宁省)
[2] 大连医科大学组胚教研室!(辽宁省)
关键词
川芎嗪; 逆转; 多药耐药性;
D O I
暂无
中图分类号
R730.53 [化学(药物)疗法];
学科分类号
100214 ;
摘要
目的 :研究具有钙拮抗作用的中药川芎嗪对多药耐药性的逆转作用。方法 :选用异搏定作阳性对照 ,观察川芎嗪 10 μg/m L 剂量下对多药耐药细胞株 K5 6 2 /A DM多药耐药性的逆转作用。结果 :川芎嗪在非细胞毒性剂量下能使 K5 6 2 /ADM对阿霉素和长春新碱的 IC5 0 降低 ,使细胞内阿霉素和柔红霉素的浓度升高 ,但对细胞表面的糖蛋白 P-170却没有影响。结论 :川芎嗪具有逆转白血病细胞株 K5 6 2 /ADM多药耐药性的作用。
引用
收藏
页码:1405 / 1407
页数:3
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