富血小板血浆注射治疗膝骨关节炎疗效观察

被引:19
作者
王加俊
匡志平
卢卫忠
曹洪辉
机构
[1] 重庆市中医院骨一科
关键词
富血小板血浆; 膝关节炎; 预后; 细胞因子;
D O I
10.13820/j.cnki.gdyx.2016.21.026
中图分类号
R684.3 [关节炎];
学科分类号
100220 [骨科学];
摘要
目的探讨富血小板血浆治疗膝关节骨性关节炎的临床疗效及作用研究。方法选取80例中度膝关节骨性关节炎患者,按照患者意愿分为对照组(n=40)和观察组(n=40)。对照组给予玻璃酸钠关节腔注射,观察组患者进行富血小板血浆关节腔注射治疗。经过4周的治疗后,通过临床症状评估、Rasmussen分级及临床疗效统计以评估治疗的效果,并比较两组患者相关细胞因子表达水平。结果两组患者治疗前的一般资料、症状积分和Rasmussen分级评分,差异均无统计学意义(P<0.05);治疗后两组患者的症状积分比较,差异有统计学意义(P<0.05),两组治疗后临床症状、体征各指标评分组间比较,除生活及工作能力、膝、跟键反射治疗后评分差异无统计学意义(P>0.05),其余项目差异均有统计学意义(P<0.05);治疗后两组患者的症状积分和Rasmussen分级评分比较,差异有统计学意义(P<0.05);对照组的总有效率达60.0%,观察组总有效率达95.0%;观察组相关细胞因子的表达水平明显低于对照组,差异有统计学意义(P<0.05)。结论对于膝关节骨性关节炎患者,采用富血小板血浆的治疗原则是早发现、早治疗,在发病早期使用其效果显著,能有效改善患者的疼痛,控制病情的迁延,降低细胞因子表达水平,值得临床推广应用。
引用
收藏
页码:3266 / 3269
页数:4
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